Chemotherapy is a kind of anti-cancer drug to treat cancer approach. Of these drugs in cell growth and proliferation of various segments of the work, inhibit or kill cancer cells.
For a long time, at home and abroad widely used treatment for breast cancer is radical surgery. However, since the 20th century, 50 years, people have the efficacy of the traditional radical surgery has raised objections because the surgery although the control of the primary cancer, but surgery alone control tumor recurrence and metastasis, after about half of patients will eventually happen is far distant metastases.
Clinical observations indicate that breast cancer is a good hair-line transfer of blood cancer, the blood line of the transfer can happen earlier in the clinical, clinical inference, according to more than half of patients about treatment when blood metastasis has already occurred, but with the current Some diagnostic methods are still difficult to detect. Therefore, although the complete resection of primary tumor, while the distribution of micro-metastasis in the body will continue to grow, eventually leading to adverse consequences.
Of breast cancer biology and immunology studies suggest that breast cancer is a kind of multi-center, characterized by occurrence of systemic disease, the early stages, even if the original lesion is very small and often there is a tiny metastasis.
Based on the above, the treatment of breast cancer must address the primary cancer and hematogenous metastasis of these two opposite, that must be taken to local treatment and systemic chemotherapy, a combination of treatments can be fully integrated control of breast cancer development, both of them difficult to achieve a radical The purpose of breast cancer.
The so-called systemic chemotherapy and local chemotherapy is based on the different ways and means of delivery, as well as after administration of drugs in vivo and tumor distribution of the different areas of division. Systemic chemotherapy usually include oral and muscle, carried out by intravenous chemotherapy, the main features of absorption of drugs through the gastrointestinal tract or from intravenous channel into the human body, drugs can reach the various tissues and organs and tumor concentration of chemotherapeutic drugs within the organization and other organizations do not have significant differences, so the systemic tumor disease and distant metastasis of advanced tumors often use this chemotherapy.
Local chemotherapy, including local tumor injection, intra-arterial infusion, intracavitary injections. Breast cancer, the liver, brain metastasis can be used when the intra-arterial infusion chemotherapy (Note: The actual work of lesser-used for reference purposes only); there chest, peritoneal transfer and transfer of associated pericardial effusion, ascites and pericardial effusion can be used when intracavitary chemotherapy. Systemic chemotherapy is the most commonly used and basic chemotherapy, local chemotherapy can improve local tumor drug concentration, give full play to the efficacy of chemotherapy drugs and reduce the toxic effects of chemotherapy and its short-term effect obvious, but long-term efficacy poor, the two complement each other to play their respective advantages and improve efficacy.
Breast cancer is a systemic disease, this view has been widely accepted in recent years, biological studies have shown that breast cancer from a single cell division and reproduction to a diameter of 1cm size of the tumor, doubled 30 times, the growth of at least more than 3 years (Note: This Office Opinions vary), hematogenous spread to the whole body provides a sufficient time, resulting in systemic treatment has become increasingly receiving more attention.
At present, the treatment of breast cancer, in addition to 0, and some other patients with stage â… , almost all patients with chemotherapy needs. The purpose of post-operative chemotherapy to reduce the distance spread, thereby enhancing long-term efficacy. Breast cancer is the application of solid tumor cancer chemotherapy, one of the most effective, and treatment of breast cancer anti-cancer drug developed rapidly, new drugs continue to emerge, gradually increase the efficacy. Better for treating breast cancer and chemotherapy drugs commonly used in the following categories: cyclophosphamide (CTX), 5 – fluorouracil (5-FU) and its derivatives, methotrexate (MTX), Vinorelbine (NVB, Novo dimension of this, NVB), adriamycin (ADM), epirubicin, cisplatin (DDP), carboplatin (CBP), paclitaxel (TAXOL), and docetaxel and so on.
