In breast cancer treatment, surgery, radiotherapy and chemotherapy is an important means of breast cancer treatment, in fact, endocrine therapy also has been the professional personnel to be associated with the above-mentioned three kinds of treatment methods are equally important position. Endocrine therapy used in breast cancer, more than 100 years of history, and because of its various means of significant effect of side effects are widely used in the treatment of breast cancer each year.
In 1896, scholars from three cases of breast cancer patients with lung metastasis in ovariectomized and found significantly reduced metastases, breast cancer, endocrine therapy and began a precedent. , People have tried surgical removal or radiotherapy endocrine organs (ovary, adrenal gland, pituitary, etc.) Although there are 1 / 3 of patients with effective, but side effects, it is difficult to accept, until the age of 60-70 the last century, isolated from estrogen receptor, endocrine therapy of breast cancer is essential to clarify the principle, endocrine therapy research and application from opening up a new chapter. Endocrine therapeutic drug use is becoming mature.
Currently considered the basic principles of endocrine therapy is part of the breast cancer patients, tumor inherent hormone receptor, in the body will produce hormones combined with tumor growth factor, promoting tumor growth. If the body by blocking receptors or decrease in hormones, so that they can not be combined, then a therapeutic effect on breast cancer. Regard, we can block the receptors in the competitive inhibition of drugs such as tamoxifen hormone receptor. Formation in the reduction of hormone are based mainly on whether the menopause to select the application of treatment, in premenopausal women the main source of ovarian hormones, so we can use drug-induced ovarian resection or surgery and radiotherapy to reduce the removal of ovarian hormone production, while the postmenopausal ovarian hormone secretion has been basically non-functional, estrogen sources are mainly from the body into male hormones, while aromatase in this process play an important role. If we use an aromatase inhibitor to aromatase resulting decrease in estrogen will be decreased, of course, testosterone, progesterone and other endocrine therapy in breast cancer also has a certain role.
The various stages of breast cancer treatment, including preoperative neoadjuvant therapy, adjuvant treatment after surgery, as well as late recurrence and metastasis of breast cancer, endocrine therapy have a very good effect. For advanced or recurrent breast cancer, and sometimes unexpected results, as we only daily oral administration of a drug, you can see significantly reduced tumor metastasis or even disappear, this is not a myth. In the secondary prevention of recurrence after surgery drug treatment, clinical trials of early breast cancer in 1990, collaborative groups, research and test summary more than 70,000 cases of patients with post-operative treatment, and concluded that over the age of 50 postoperative patients with breast cancer adjuvant endocrine better than the adjuvant chemotherapy treatment. The data suggest that in 1998 three pairs of postoperative oxygen therapy five years with no amine can reduce the recurrence of 47% compared to reduce deaths 26%. The latest research information (ATAC trial, Big198 test, IES031 test, etc.) then you are prompted for postmenopausal hormone receptor-positive breast cancer, the application of aromatase inhibitor tamoxifen to prevent breast cancer recurrence off than those applied to further enhance efficacy.
Endocrine therapy in patients with cancer of the condition that inspection of hormone receptor positive. Post-menopausal patients better in China, although the proportion of patients without post-menopausal high-western countries, there is still a large number of breast cancer patients benefit from endocrine therapy is evident, its main advantage lies in its efficacy with the same side effects with chemotherapy is very small. I believe as people of endocrine therapy to further deepen the understanding of endocrine therapy in breast cancer treatment at all stages will play a bigger role.
