1. Radionuclide bone scan (ECT) is a screening diagnostic method of bone metastasis. A high sensitivity, early detection, missed the advantages of whole body imaging is not easy. But the presence of specific low, divided into easy, or osteolytic bone lesions, but also can not show the shortcomings of the extent of bone destruction. Bone ECT examination is recommended for breast cancer bone pain occurs, fractures, alkaline phosphatase increased, or hypercalcemia such as suspected bone metastases routine screening diagnostic tests; breast cancer staging> T3N1M0 patients further conventional sub – inspected. ECT is also selective examination of bone in patients with conventional staging for breast cancer examination.
2. Magnetic Resonance Imaging (MRI), or CT scan, or X ray film is the imaging diagnosis of bone metastasis inspection methods. For the bone scan abnormalities in patients with ECT, it should be against the suspected site of bone metastasis to MR, or CT, or X ray film examination to diagnosis of bone metastasis diagnosis, and to understand the severity of bone destruction.
3.PET-CT (positron emission tomography) can be a direct response to tumor cells to glucose intake, clinical studies have been prompted to FDG-PET and bone scans have a similar sensitivity, higher specificity, for of bone metastasis of breast cancer after treatment is superior to bone scans to track the disease, but the Group believes that the current PET-CT in the diagnosis of bone metastases needs further research, clinical, not as a routine recommendation.
Therefore, the clinical diagnosis of bone metastasis, ECT can be used as screening, X-ray, CT, MRI can clearly whether the bone destruction, PET-CT in the value of further study, the clinical application of various diagnostic methods should be reasonable, if necessary, need to Pathological diagnosis of bone obtained by biopsy.
For the diagnosis of breast cancer patients with bone metastases, which further routine inspections: routine blood test, creatinine, calcium and other biochemical indicators of liver and kidney functions and blood screening; chest, abdomen, pelvic imaging examination.