Endocrine therapy is directly aimed at stimulating factor and development of breast cancer treatment, by inhibiting or reducing the related hormone secretion, reducing its levels for therapeutic purposes, the value of no less than surgery, chemotherapy and radiotherapy, and in many cases it also has other measures can not be replaced, even unparalleled advantage. Endocrine therapy more targeted and selective toxicity tend to be more relaxed, but its therapeutic value in the appropriate patients are enormous, and we are often overlooked in the clinical work it. Thus, doctors and patients should be assured that the use of hormonal therapy, so that more estrogen receptor-positive patients from the chemotherapy side effects, have a healthy, happy every day.
A recent global survey showed: 70% of specialist physicians that, for those who have received treatment for women with early breast cancer, the greatest fear is that cancer recurrence and metastasis, such a fear even more than they are for the first time that they suffered from breast cancer. Breast cancer is currently the treatment of cancer, one of the best, as long as the risk of successful control of recurrent breast cancer patients can have a very long lifetime.
Breast-conserving surgery often choose an earlier stage of disease of breast cancer, tumor size ≤ 3cm usually isolated lesions, if a larger tumor should also take into account the proportion of breast tumor size was; if less than a mass touch, only isolated clusters smile calcification by “three-dimensional positioning” excision biopsy confirmed breast cancer, but also feasible to breast-conserving surgery; tumor location usually the tumor is located in the nipple, areola edge of the breast-conserving tumor edge away from the edge of the areola ≥ 2cm, so after breast-conserving shape the impact will be smaller.
In general, the common sites of metastases of breast cancer followed by lung and pleura, bone, skin and soft tissue, liver, brain. For the different parts of the transfer, its treatment methods and therapeutic effects vary.
Lung breast cancer the most common sites of metastases. Generally start with the performance of dry cough, chest tightness, shortness of breath and so on antibiotic treatment ineffective. Commonly used method for the treatment of chemotherapy, generally make more than 60% of patients with lesions in the short term to reduce or to completely subside.
Receptor-negative breast cancer three histological differential, the prognosis is poor, its endocrine treatment and the target for the HER2
Are not suitable for the treatment of this sub-group, chemotherapy is the only systemic therapy, the current breast cancer treatment guidelines do not address this sub-group of the recommended treatment.
Receptor-yin and breast cancer accounted for 10% of all breast cancer -17%, the age of onset of triple-negative breast cancer compared with non-small (53:57.7, P <0.0001), more occurred in the following women: age of menarche, and full-term pregnancy, early and short duration of breast-feeding, high body mass index and waist-hip ratio, especially in pre-menopausal patients, also showed that the use of suppression of lactation in breast-feeding populations have a higher risk of basal-like breast cancer.
At present the immunohistochemical staining characteristics, the ER, PR, HER2 receptor-negative breast cancer are called receptor-3-negative breast cancer by gene chip technology for breast cancer sub-type found in the receptor-negative breast 3 carcinoma and basal-like subtype of breast cancer have a high consistency, recurrence of early, rapid development, survival is short, for the triple-negative breast cancer treatment, there is no recommended treatment options, while the targeted therapy in triple-negative breast cancer the position is not clear.
Of life’s basic purpose is to insecurity in the world to adapt to stress, crisis management, in order to maintain body balance. Rarely in a variety of diseases like cancer, to patients with great mental stress. Cancer not only affects a person’s normal life, but also jeopardized the family, not only damaged the normal function of the body and cause changes in body image; and the patient’s role in the family conversion, increased fear, anxiety, depression, anger, guilt, despair and other emotions reaction.
In all genotypes in breast cancer, basal-like breast cancer (Basal-like)-type breast cancer basal-like breast cancer, despite the worst prognosis by gene expression technology spectrum, the distinction between the subtypes of breast cancer. With “basal-like” breast cancer, the word is that this type of breast cancer, the molecular characteristics, and normal breast basal cell is very similar. Back in a long time ago has proven that this type of breast cancer characteristics of poor prognosis [1-2], the lack of specific treatment methods, but the pathogenesis of basal-like breast cancer is not very clear, as the abnormal proliferation and metastasis of tumor characteristics of the reasons for is not very clear.
Diagnosis of breast cancer clinical stage should be set at the same time. The so-called staging, it simply is the delineation of what the scope of the disease when diagnosed with breast cancer, to facilitate the treatment plan and estimate the prognosis and efficacy of the formulation. TNM staging of breast cancer is now widely used, and their professionalism and strong, in order to facilitate the general reader to understand, are described in broad terms about the clinical stage of breast cancer.